David de Gea was seen limping off the field while the rest of his team mates took part in the pre-match warm up. He appeared to go over on his ankle, before taking off his gloves, then walking to the dressing room.
With such a youthful side, with youngsters Donald Love and Paddy McNair playing at the back, the former making his first start for the club, United could do with the experience of De Gea more than ever.
Sergio Romero starts for United and the club now have no goalkeeper on the bench.
Made in Manchester is available for just £5. It includes 30 articles from the country's best football writers about graduates from the Manchester United academy. Everyone who buys a copy enters a competition to win the new home shirt. All profit goes to Trafford Macmillan so please support this fantastic cause.