United’s 2-0 victory at Bournemouth on Wednesday moved them four points clear of Liverpool with four games to play and they are strongly fancied to end the season as runners-up behind Manchester City.
The Red Devils host Arsenal on April 29, before visiting Brighton & Hove Albion and West Ham United in their next two games.
United round off their season at home to Watford and nine points from that quartet of games would guarantee them second spot.
Arsenal looks United’s trickiest game, although the Gunners may be distracted by their Europa League semi-final tie against Atletico Madrid which is scheduled to take place either side of their trip to Old Trafford.
Arsene Wenger’s decision to step down as manager at the end of the season could see the club completely focus its efforts on the Europa League to try and give the Frenchman the perfect send-off.
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Both Brighton and West Ham are in desperate need of points as they bid to steer clear of relegation and both have taken a point off sides in the top five over the past couple of weeks.
However, United’s performance at Bournemouth highlighted their quality against the lower sides and it’s difficult to imagine them not picking up at least four points from those two away games.
United’s final game against Watford on May 13 should be a home banker, with the Hornets virtually safe from relegation and probably in holiday mode by the time they visit Old Trafford.
Tottenham Hotspur are just two points behind Liverpool, but the Merseyside club appear to be United’s only realistic challengers for the second spot.
Liverpool start their final four fixtures with a trip to face bottom-of-the-table West Bromwich Albion, before welcoming lowly Stoke City to Anfield the following week.
Jurgen Klopp’s side head to Chelsea on May 6 and this fixture could be the one that ends their hopes of finishing second.
Chelsea have failed to replicate the form that saw them sweep to the title in 2016/17 and Liverpool will fancy their chances of success having won on their last two visits to Stamford Bridge.
However, Chelsea are still in the running for a top-four spot after their 2-1 win at Burnley and they are unlikely to make things easy for the visitors.
A home game against Brighton on the final day of the season should be a home win for the Reds, but United are big favourites to secure the runners-up spot.