Anthony Martial and Marouane Fellaini have returned from the international break with injuries, while Wayne Rooney is ill.
So far this season, striker James Wilson has played eight minutes against Arsenal and 45 minutes against Middlesbrough in the League Cup.
Louis van Gaal has confirmed he is fit to play but wouldn’t be available for the full 90 minutes due to a lack of match fitness.
Wilson is okay after the international break. He can play but he cannot play a whole match because he doesn’t have the rhythm of the game.