United are a top priced 1.25 to beat Fulham and look bankers to do the double over their rivals and maintain their position as league leaders.
The Red Devils have been in outstanding form at league level, winning eight and drawing once in the last nine games.
The only dropped points came when they came from 3-0 deficit at Chelsea to draw 3-3, and they were unlucky not to come away with maximum points that day.
They hammered Fulham 5-0 on their own patch just before Christmas with a ruthless display with Danny Welbeck, Nani, Ryan Giggs, Wayne Rooney and Dimitar Berbatov all getting on the scoresheet and the stats suggest a similar outcome could be on the cards.
Sir Alex’s men have won their last seven Premier League games at Old Trafford against the Cottagers, with the Londoners failing to score in their last four.
In fact their only goal in the previous match was an own goal by Rio Ferdinand, and Martin Jol has also never beaten United during his time as a manager in the Premier League.
On the team news front, the gaffer will be picking from strong squad with Nani (ankle), Anders Lindegaard (ankle) and Michael Owen (thigh) the only absentees, along with long-term casualties Nemanja Vidic and Darren Fletcher.
Chris Smalling, Tom Cleverley, Fabio, Paul Pogba and Phil Jones all available after coming through a reserve outing on Thursday.
Not surprisingly the bookies are running scared of Wayne Rooney in their goalscorer markets.
Wazza has scored 16 goals in his last 16 appearances in all competitions and netted five times in his last four appearances against Fulham at Old Trafford.
However better value Chicharito to bag the opener at 4.5 with Betfred.
He netted twice in United’s 5-0 romp over Wolves and is looking better and better with every game.
Whoever scores first I do expect United to win this with plenty to score and without reply.
In their current form they are capable of running riot and winning 4-0 or 5-0, and a small punt on both those outcomes at 12 with Boylesports and 26 with Paddy Power respectively will hopefully produce some juicy profit.
The RoM 2016-17 Season Preview is available for just £5. It includes an EXCLUSIVE interview with Mikael Silvestre, a Q&A with the country's top journalists about our transfer targets, articles by brilliant United writers, and so much more. All profit goes to Trafford Macmillan so please support this fantastic cause.