Sir Alex Ferguson’s side have a terrific record against the Londoners and come into the game unbeaten in their last 6 matches in all competitions despite not playing at their best.
They have won 17 and lost none of their last 22 Premier League games against Tottenham, and the Lilywhites have managed to score eight goals in 20 Premier League visits to Old Trafford.
The last player to score a winning goal for them in Manchester was actually Gary Lineker in December 1989, which highlights the dominance that the Red Devils have had over their rivals for over two decades.
Wayne Rooney, who had a run out against Newcastle in their capital One Cup win in midweek, has scored seven goals in his last eight Premier League appearances against Spurs and five in the last five.
That makes him of obvious interest in the first goalscorer market at 5.5 with Boylesports, but my money is going to be going on Robin van Persie who was rested in midweek and has made a great start to his career as a United player.
The Dutchman has scored five goals in his last six Premier League home games against Spurs, and can be backed at huge looking 5 with Paddy Power to bag the opener.
I think he can fire United to a comfortable victory and like the look of a 3-1 or 4-1 success for United.
Those outcomes have been priced up at 12 and 21 respectively by bet365.